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THE LENGTH OF LIFE OF RED BLOOD CORPUSCLES

JAMA. 1919;72(20):1467. doi:10.1001/jama.1919.02610200039020.
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The question as to the usual length of life of the red blood corpuscles has come to have more than mere academic interest. Erythrocytes form an important part of every portion of blood that is transfused from one person to another. Ashby9 has clearly pointed out that whether transfused blood corpuscles live and function for any considerable length of time or whether the beneficial results that have been observed to follow transfusion, outside the purely mechanical part of increasing the bulk of the depleted blood, are due to a stimulating effect on the hematopoietic function by the product of the broken down corpuscles is still an open question.

When red corpuscles disintegrate, they liberate the pigmentary portion of their constituent hemoglobin. This can be converted into bile by the liver and also excreted as fecal pigments. The fact that these are constantly leaving the body has furnished a reason

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