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April 5, 1919, Vol 72, No. 14 >
ARTICLE | April 5, 1919

SUPERIORITY OF THE METHOD OF ICE-BOX FIXATION IN THE WASSERMANN TEST

Oscar Berghausen, B.A., M.D.
JAMA. 1919;72(14):996. doi:10.1001/jama.1919.26110140004011c.
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In 1917, Smith and MacNeal reported results obtained in a comparative study of different antigens and of different temperatures of incubation in the Wassermann test. Last summer the method of ice-box fixation was employed at the Cincinnati General Hospital with such gratifying results that it is now employed as a routine. Previously the classical test in which three different antigens were used, a double unit of complement and amboceptor, in a final volume of 2.5 c.c., with incubation at 37 C. in a water bath, was employed. Comparative studies have convinced us that when small amounts of antigen are used with fixation at the low temperatures of 0 and 2 C., false positive reactions are avoided and reliable results are obtained.

PREPARATION OF ANTIGENS AND THE TECHNIC OF THE TEST  The cholesterinized antigen was prepared by treating 100 gm. of beef heart with 900 c.c. of alcohol in the usual

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