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TAKING CHANCES IN BLOOD TRANSFUSION

JAMA. 1919;72(11):797-798. doi:10.1001/jama.1919.02610110029010.
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Transfusion of blood or blood constituents has become a necessity in modern clinical practice. Its general utility is unfortunately still limited by a number of difficulties of technic and incompatibilities of blood that have not been satisfactorily mastered. None of our present methods—the syringe cannula, the paraffined tube and the citrated blood procedures—are absolutely free from all objectionable features, among which unanticipated hemolysis, agglutination of the corpuscles, and febrile reactions are included. Of the dangers due to incompatibility we shall consider particularly those due to agglutination rather than those due to lysis.

In 1900, Landsteiner first suggested that human beings might be divided into definite groups according to whether or not the. corpuscles of one were agglutinated by the serum of the other, or vice versa. His preliminary grouping into three classes was subsequently shown to be somewhat inaccurate, and numerous examinations made since that time have definitely shown that

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