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Comment & Response |

Perioperative Treatment With Aspirin or Clonidine and Risk of Acute Kidney Injury

Jianzhong Sun, MD, PhD1; Hong Liu, MD2
[+] Author Affiliations
1Department of Anesthesiology, Thomas Jefferson University and Hospitals, Philadelphia, Pennsylvania
2Department of Anesthesiology and Pain Medicine, University of California Davis Medical Center, Sacramento
JAMA. 2015;313(11):1166. doi:10.1001/jama.2015.1055.
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To the Editor A large randomized clinical trial,1 which was a substudy of the Perioperative Ischemia Evaluation-2 (POISE-2) trial,2 reported that among patients undergoing major noncardiac surgery, perioperative use of aspirin or clonidine did not reduce the risk of acute kidney injury. Aspirin actually increased the risk of major bleeding and clonidine increased the risk of hypotension. We have several comments and concerns.


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March 17, 2015
P. J. Devereaux, MD, PhD; Daniel I. Sessler, MD; Amit X. Garg, MD, PhD; for the POISE-2 Investigators
1Population Health Research Institute, Hamilton, Ontario, Canada
2Cleveland Clinic, Cleveland, Ohio
3Western University, London, Ontario, Canada
JAMA. 2015;313(11):1166-1167. doi:10.1001/jama.2015.1061.
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