We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Comment & Response |

BK Virus Prophylaxis With Levofloxacin

Gijs W. D. Landman, MD, PhD1
[+] Author Affiliations
1Department of Internal Medicine, Gelre Hospital, Apeldoorn, the Netherlands
JAMA. 2015;313(11):1165. doi:10.1001/jama.2015.1052.
Text Size: A A A
Published online


To the Editor Dr Knoll and colleagues1 performed a randomized clinical trial of BK virus prophylaxis with levofloxacin after kidney transplantation. The authors did not find a reduction in BK viruria, the primary outcome, with approximately 30% of patients developing low-level viruria and 10% viremia.

The current strategy to prevent BK nephropathy is screening for BK viruria followed by intensive monitoring and reductions in immunosuppressive medication when viruria progresses or viremia develops. Although the authors primarily aimed to lower viruria, I am interested in their opinion on whether the difference in percentages of patients who do not need a dose reduction of immunosuppressive medication could also be an appropriate surrogate end point for future studies.


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview




March 17, 2015
John S. Gill, MD, MS; Greg A. Knoll, MD; Atul Humar, MD
1Division of Nephrology, University of British Columbia, Vancouver, Canada
2Division of Nephrology, University of Ottawa, Ottawa, Ontario, Canada
3Department of Medicine, University of Toronto, Toronto, Ontario, Canada
JAMA. 2015;313(11):1165-1166. doi:10.1001/jama.2015.1058.
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

See Also...