REACTION OF LEUKOCYTES AFTER VACCINATION WITH ARMY TRIPLE TYPHOID LIPOVACCINE

Courmont and Devic¹ found that injection of typhoid and paratyphoid saline vaccines quickly cause a leukocytosis marked by polynucleosis with neutrophilic myelocytosis. In several cases after the use of an ether-killed vaccine, a mild mononucleosis followed the phase of polynucleosis. After the use of a heat-killed vaccine, mononucleosis following polynucleosis was a rarity. Hallion and Mery,² in their study of the modifications of postvaccinal leukocytosis after successive doses of heat-killed T. A. B. vaccine, found that their results agreed with those of Courmont and Devic to the extent that a polynuclear leukocytosis followed the injection of the vaccine which later gave place to mononucleosis. They found, also, that the leukocytic reactions after successive doses became progressively less intense. Mery and Girard³ found that the polynucleosis following the injection of the heat-killed T. A. B. vaccine is independent of the method of injecting the vaccine. They found that