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EXPERIMENTAL MEASLES A REVIEW

LUDVIG HEKTOEN, M.D.
JAMA. 1919;72(3):177-180. doi:10.1001/jama.1919.02610030023008.
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In view of the increasing interest in the study of measles and its complications, it may be of advantage to survey briefly the results of the efforts to produce measles experimentally. The experiments in question fall in two groups, those on human beings and those on animals, especially monkeys.

EXPERIMENTAL MEASLES IN MAN  So far as known, the first attempt to inoculate man with measles was made by Francis Home in Edinburgh in 1758. The suggestions probably came from Alexander Monroe the Second, and the purpose was not to study the nature and seat of the virus but to insure the disease "in a gentle and favorable degree" in the hope that many might "be preserved from that malignant sort which often proves mortal, and is always dangerous." Home1 ordered a very superficial incision to be made "amongst the thickest of the measles, and the blood which came slowly

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