JAMA. 1918;71(26):2156. doi:10.1001/jama.1918.02600520042014.
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The justification for a careful consideration of the subject of antiscorbutic agents is presented by the recent studies of experimental scurvy.1 McCollum2 remarked recently in a symposium on diseases due to deficiencies in nutrition:

Recovery from scurvy following a change of diet, or an improvement of the bacteriologic condition of the food, or following the administration of substances having diuretic properties, may be more satisfactorily explained in other ways than by the assumption that such changes in the dietary regimen produce their effects because of the introduction of a hypothetic antiscorbutic substance. It is necessary, henceforth, that those who discuss the etiology of scurvy should take into consideration the results of recent researches in nutrition with simplified diets. Whoever would seek to establish the validity of the theory of the existence of a specific antiscorbutic substance should first furnish new explanations for the experimental results that are not


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