Drs Hutten and Hovingh contributed equally to this work.
Study concept and design: Besseling, Hutten, Hovingh.
Acquisition, analysis, or interpretation of data: Besseling, Kastelein, Defesche, Hutten, Hovingh.
Drafting of the manuscript: Besseling, Defesche, Hutten, Hovingh.
Critical revision of the manuscript for important intellectual content: Besseling, Kastelein, Defesche, Hutten, Hovingh.
Statistical analysis: Besseling, Hutten.
Obtained funding: Kastelein, Hovingh.
Administrative, technical, or material support: Besseling, Defesche, Hovingh.
Study supervision: Hutten, Hovingh.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Kastelein reports receipt of a VENI grant from the Netherlands Organisation for Scientific Research (NWO, project number 91612122) and support by grants from the CardioVascular Research Initiative (CVON2011-19; Genius) and the European Union (TransCard, FP7-603091-2); receipt of lecture fees for Dr Hovingh from Amgen, Pfizer, Roche, and Sanofi; and a research grant from AstraZeneca. Dr Kastelein reports being a recipient of the Lifetime Achievement Award of the Netherland Heart Foundation (NHS, project number 2010T082) and receipt of lecture grants from Aegerion, AstraZeneca, Boehringer Ingelheim, Cerenis, Eli Lilly, Genzyme, JSiS, MSD, Novartis, Pfizer, Regeneron, Roche, and Sanofi. No other disclosures were reported.
Additional Contributions: We are most grateful to all patients who participated in the cascade screening program. We would also like to thank the genetic field workers for their effort in collection of the data.