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Comment & Response |

Left Atrial Appendage Closure for Atrial Fibrillation—Reply

Vivek Y. Reddy, MD1; David Holmes, MD2
[+] Author Affiliations
1Helmsley Electrophysiology Center, Mount Sinai School of Medicine, New York, New York
2Mayo Clinic College of Medicine, Rochester, Minnesota
JAMA. 2015;313(10):1057-1058. doi:10.1001/jama.2015.0685.
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In Reply Drs Stöllberger and Schneider raise a number of questions about our article. First, with regard to baseline patient characteristics, as stated in the Results section, there were no significant differences in principal baseline characteristics between the groups.

Second, the number of patient-years in Table 2 varies between end points because cumulative patient-years for each row were determined by the time to first event. In the case of the primary end point, the first event could be any component of the composite, whereas the individual rows would only include patients experiencing the specific outcome listed, thus allowing for small variations in the denominator.


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March 10, 2015
Claudia Stöllberger, MD; Birke Schneider, MD
1Krankenanstalt Rudolfstiftung, Wien, Austria
2Sana Kliniken, Lübeck, Germany
JAMA. 2015;313(10):1057. doi:10.1001/jama.2015.0682.
November 19, 2014
Vivek Y. Reddy, MD; Horst Sievert, MD; Jonathan Halperin, MD; Shephal K. Doshi, MD; Maurice Buchbinder, MD; Petr Neuzil, MD, PhD; Kenneth Huber, MD; Brian Whisenant, MD; Saibal Kar, MD; Vijay Swarup, MD; Nicole Gordon, BSEE; David Holmes, MD; for the PROTECT AF Steering Committee and Investigators
1Mount Sinai School of Medicine, New York City, New York2St John’s Health Center, Santa Monica, California3Homolka Hospital, Prague, Czech Republic
4Cardiovascular Center Frankfurt, Sankt Katharinen, Frankfurt, Germany
1Mount Sinai School of Medicine, New York City, New York
2St John’s Health Center, Santa Monica, California
5Foundation for Cardiovascular Medicine, La Jolla, California
3Homolka Hospital, Prague, Czech Republic
6St Luke’s Hospital, Kansas City, Missouri
7Intermountain Medical Center, Murray, Utah
8Cedars Sinai Medical Center, Los Angeles, California
9Arizona Heart Rhythm Center, Scottsdale
10Boston Scientific, St Paul, Minnesota
11Mayo Clinic College of Medicine, Rochester, Minnesota
JAMA. 2014;312(19):1988-1998. doi:10.1001/jama.2014.15192.
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