0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Editorial |

Does the LDL Receptor Play a Role in the Risk of Developing Type 2 Diabetes?

David Preiss, MD, PhD1; Naveed Sattar, MD, PhD1
[+] Author Affiliations
1BHF Glasgow Cardiovascular Research Centre, University of Glasgow, United Kingdom
JAMA. 2015;313(10):1016-1017. doi:10.1001/jama.2015.1275.
Text Size: A A A
Published online

Extract

Over the last 5 years, major randomized clinical trials and meta-analyses of these trials have indicated that statin therapy, which inhibits 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), is associated with a modestly higher risk of developing diabetes in a dose-dependent fashion.1,2 Statins act by reducing the synthesis of cholesterol, which then drives an increase in hepatic low-density lipoprotein (LDL) receptor expression, the key step leading to a reduction in circulating LDL cholesterol levels. Further supportive data for this relationship have emerged from genetic studies, typically less prone to confounding than observational studies, which have linked genetically determined lower LDL cholesterol to higher diabetes risk.3,4 In one such study, individuals with lower circulating LDL cholesterol due to variants in the HMGCR gene, a proxy for statin therapy, displayed higher glucose levels, higher weight, and increased diabetes risk,3 consistent with data from randomized clinical trials. However, the exact mechanism by which any such effect is mediated remains unclear.

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

3,528 Views
2 Citations
×

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

See Also...
Articles Related By Topic
Related Collections
PubMed Articles
Jobs
brightcove.createExperiences();