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JAMA. 1918;70(23):1765-1766. doi:10.1001/jama.1918.02600230035013.
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Recent work on hay-fever, asthma, eczema, urticaria and angioneurotic edema is being rewarded with interesting results. It has been noted that these various diseases are frequently associated in one family and occasionally even in one individual. Formerly, hay-fever was regarded as due to "a predisposing— perhaps neurotic—idiosyncrasy, a resulting hyperesthesia" and "an exciting agent"—pollen in true hay-fever, unfavorable atmospheric conditions in so-called pseudohay-fever. Now, however, not only has stress been placed on the resemblance of the symptoms in hay-fever, asthma and allied conditions to some of those of active anaphylaxis (by Wolff-Eisner, Meltzer and others) but, as Koessler1 says, it has been proved by experiment that hay-fever is a disease due to pollen protein sensitization. It has been shown also that asthma in certain cases may be precipitated by inhalation, by subcutaneous injection or by ingestion of the foreign protein to which the individual is sensitized, as in horse


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