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A. H. Sanford, M.D.
JAMA. 1918;70(17):1221. doi:10.1001/jama.1918.26010170003012a.
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It is well known that the iso-agglutinins in human serum are thermostabile, and it occurred to me that agglutinating properties in human serum might be easily preserved by drying. The experiment was made as follows to determine this point: Cover slips were cleaned and dried. On several of these were placed two loopfuls of serum from persons of Group III. In like manner cover slips were prepared, with serum from Group II persons. These droplets of serum were allowed to dry in the air, and were then wrapped in paper and placed in the ice box. After more than two months they still possessed marked agglutinating properties. To demonstrate this, one loopful of corpuscle suspension of a Group II person was used to dissolve the dried Group III serum on one of the cover slips. When this was inverted over the concavity on a hanging drop slide, it was noted


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