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JAMA Clinical Evidence Synopsis |

Pharmacological Interventions for Sleepiness and Sleep Disturbances Caused by Shift Work

Juha Liira, MD, PhD1; Jos Verbeek, MD, PhD1; Jani Ruotsalainen, MSc1
[+] Author Affiliations
1Finnish Institute of Occupational Health, Helsinki, Finland
JAMA. 2015;313(9):961-962. doi:10.1001/jama.2014.18422.
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Clinical Question  Are pharmacological interventions associated with better-quality sleep and alertness in shift workers?

Bottom Line  Low-quality evidence shows that melatonin is associated with 24 minutes longer daytime sleep after the shift but not with faster falling asleep compared with placebo. There is no association between hypnotics, such as zopiclone, and sleep outcomes, alertness, or harms. The alertness-promoting medications armodafinil and modafinil are associated with improved alertness during shift work but are also associated with headache and nausea.

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The Association of Melatonin With Self-Reported and Objectively Measured Sleep Duration During Days After the Night Shift

Source: Data have been adapted with permission from Wiley.6 Two studies only reported night sleep after the night shift period and could not be included. The size of the data markers indicate the weight of the study.

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