Following the appearance of the paper by Cabot and Crabtree,1 setting forth the favorable results obtained from the administration of colon vaccine in a series of eight prostatic cases, the procedure was adopted from time to time in the Mayo Clinic; but not until May, 1917, was it systematically carried out. At about this time also there appeared an article by von Sholly,
Blum and Smith2 on the therapeutic value of bacterial vaccine in whooping cough, the authors stating that during the administration of the vaccine they were very enthusiastic as to the beneficial results. After their tables had been compiled, however, and carefully compared with the controls, the results showed that the untreated patients had done, on the whole, better than those receiving the vaccine. Similarly, Whittington3 reported on 230 typhoid cases with careful controls and, interestingly enough, he also felt confident of favorable results until