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JAMA. 1913;61(14):1300-1302. doi:10.1001/jama.1913.04350150056022.
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THE CALL OF THE EMPTY STOMACH  If it be true, as was suggested in our recent discussion of the contractions of the stomach attending the sensation of hunger,l that the actual stimulus to these is inherent in some local gastric mechanism rather than in general systemic conditions, it might be expected that the hunger contractions would appear as soon as the stomach is empty of food or other substances capable of stimulating the mucosa. It is a physiologically advantageous arrangement whereby the inhibition of the hunger contractions by mechanical and chemical stimulation of the gastric membrane prevents the appearance of these contractions during the period of gastric digestion. It would not be stange, however, if psychic and other factors, such as habit, fatigue, etc., interfered in daily life with the expected manifestation of hunger immediately after the emptying of the stomach. As a matter of fact, most of us probably do not always experience the sensation of hunger at every period when the stomach is

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