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ARTICLE |

SYMPTOMATOLOGY OF MULTIPLE SCLEROSIS

L. HARRISON METTLER, A.M., M.D.
JAMA. 1913;61(7):474-477. doi:10.1001/jama.1913.04350070028010.
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Patient.—  Mrs. F., aged 43, married twenty-two years, housekeeper, was seen in consultation with Dr. M. Barker. The father, aged 70, in fine health, does not drink, uses tobacco moderately and never had any severe, prolonged disease. The mother died of consumption when patient was an infant. Brothers and sisters are all healthy. Patient has five well-developed children; never had a miscarriage.

History.—  The patient's birth was natural and she never had convulsions. Childhood was quite uneventful. School life was normal. Menstruation began early and still occurs regularly and painlessly, though rather profusely. The patient was well till fourteen years ago when she experienced an attack of paralysis, first on the left and then on the right side. She remembers a distinct tingling sensation traveling up the legs and arms. No disturbance of consciousness occurred with this attack of paralysis. There was some difficulty in controlling the bowels and she

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