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THE JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

JAMA. 1913;60(11):832-837. doi:10.1001/jama.1913.04340110038018.
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THE BLOOD IN ANAPHYLACTIC SHOCK  Under the influence of scientific investigation the unique biologic phenomenon which has been designated as anaphylaxis is slowly beginning to unfold its character and disclose the underlying chemical reactions which are responsible for its remarkable manifestations. It has previously been noted that the injection of foreign protein into the circulation is followed by a noteworthy response in the nature of the appearance of enzymes of the proteolytic type capable of digesting the new substance introduced into the blood. One is at once inclined to ask the significance of the newly developed plasma enzyme. Is it provided by the organism to disintegrate the foreign protein and thus give an opportunity for its physiologic removal from the blood-stream? And, if so, are the proteolytic digestion products responsible for the phenomena of the so-called anaphylactic shock? It is well known that the protein derivatives of the proteose or

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