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JAMA. 1910;55(25):2161-2162. doi:10.1001/jama.1910.04330250057018.
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READY-MADE MIXTURES  There is little doubt that the tendency in some quarters to underestimate the value of drugs in the treatment of disease is due to the unscientific way in which drugs have been used rather than to the lack of efficacy of the drugs themselves. No reliable conclusions can be deduced regarding the use of drugs unless the administrators of such drugs know the exact amounts that have been used; in other words, accuracy of dosage is essential to scientific therapeutics. In the Pharmacology Department of this issue, one of the reasons for unscientific prescribing is made clear. There are on the market tablets containing bismuth, opium and phenol in varying (alleged) proportions. Whether these tablets were originally made by the various manufacturing pharmaceutical houses in response to a demand by physicians or, as is more likely, were put out by an enterprising firm to catch the physician's fancy


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