Study concept and design: Wang, Midthun, Yang.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Wang, Midthun, Deng, Zhang, Yang.
Critical revision of the manuscript for important intellectual content: Wang, Midthun, Wampfler, Stoddard, Yang.
Statistical analysis: Wang, Midthun, Wampfler, Deng, Zhang, Yang.
Obtained funding: Yang.
Administrative, technical, or material support: Wang, Yang.
Study supervision: Midthun, Yang.
Conflict of Interest Disclosures: The authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest and none were reported.
Funding/Support: This study was supported by grants R03 CA77118, R01 CA80127, and R01 CA84354 from the National Institutes of Health, grant R01 AG034676 from the National Institute on Aging, and funding from the Mayo Clinic Foundation.
Role of the Sponsor: The National Institutes of Health, the National Institute on Aging, and the Mayo Clinic Foundation had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Contributions: We thank Barbara A. Abbott, Jennifer L. St Sauver, PhD, and Walter A. Rocca, MD (Department of Health Sciences Research, Mayo Clinic), and Barbara P. Yawn, MD (Department of Research, Olmsted Medical Center), for their assistance in preparing the manuscript. We also appreciate Khadija Idiris for her technical assistance with the manuscript. No compensation was received by any of these individuals.