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JAMA. 1910;55(4):311-312. doi:10.1001/jama.1910.04330040047016.
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It is a well-known fact that certain drugs acquire their highest therapeutic efficiency in combination with other drugs. In such combinations not only is their therapeutic effect increased, but in addition possible disagreeable by-effects are neutralized and not infrequently the therapeutic action of the adjuvant is made more prominent. As familiar examples of such combinations may be mentioned iron and arsenic, mercury and potassium iodid, quinin, iron and arsenic or strychnin. Furthermore, I have observed that the disagreeable effects of chloral may be minimized by combining it with a bromid, codein or morphin. Well-known are the excellent results which have been obtained by the combination of morphin and atropin, morphin and scopolamin, cocain and adrenalin, and lately a combination of physostigmin and pilocarpin has been highly recommended in the treatment of glaucoma. In this connection I will discuss a number of combinations of narcotics with the synthetic antipyretics, drugs which


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