Authors Contributions: Dr Despriet had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Klaver, Hofman, Oostra, Uitterlinden, Van Duijn, De Jong.
Acquisition of data: Klaver, Kardys, Boekhoorn, Vingerling, Uitterlinden.
Analysis and interpretation of data: Despriet, Klaver, Bergen, Witteman, De Maat, Vingerling, Stijnen, Van Duijn, De Jong.
Drafting of the manuscript: Despriet, Klaver.
Critical revision of the namuscript for important intellectual content: Klaver, Witteman, Bergen, Kardys, De Maat, Boekhoorn, Vingerling, Hofman, Oostra, Uitterlinden, Stijnen, Van Duijn, De Jong.
Statistical analysis: Despriet, Klaver, Witteman, Stijnen.
Obtained funding: Bergen, Hofman, De Jong.
Administrative, technical, or material support: De Maat, Hofman, Uitterlinden.
Study supervision: Klaver, Vingerling, Hofman, Van Duijn, De Jong.
Financial Disclosures: None reported.
Funding/Support: This study was supported by the Netherlands Organization for Scientific Research (the Hague), Optimix (Amsterdam), Swart van Essen (Rotterdam), Neyenburgh (Bunnik), Physico Therapeutic Institute (Rotterdam), Blindenpenning (Amsterdam), Sint Laurens Institute (Rotterdam), Bevordering van Volkskracht (Rotterdam), Blindenhulp (the Hague), Rotterdamse Blindenbelangen Association (Rotterdam), OOG Foundation (the Hague), Ooglijders (Rotterdam), Prins Bernhard Cultuurfonds (Amsterdam), Van Leeuwen Van Lignac (Rotterdam), Verhagen (Rotterdam), the Netherlands Society for the Prevention of Blindness (Doorn), and Elise Mathilde (Maarn). An unrestricted grant was obtained from Topcon Europe BV (Capelle aan de IJssel).
Role of the Sponsors: The study's sponsors had no role in the design and conduct of the study; in the collection, analysis, and interpretation of the data; or in the preparation, review, and approval of the manuscript.
Previous Presentations: Part of this study was presented at the 29th Annual Macula Society Meeting in Carlsbad, Calif, on February 23, 2006; and at the Association for Research in Vision and Ophthalmology Annual Meeting in Fort Lauderdale, Fla, on May 2, 2006.
Acknowledgments: We thank Ada Hooghart and Corina Brussee for grading of fundus photographs, Pascal Arp for genotyping, and statistician Paul Mulder, PhD, for his excellent advice on statistical analyses. All of these individuals were paid by different groups (and partly by grants) within the departments of epidemiology, biostatistics, and internal medicine at Erasmus Medical Center, Rotterdam, the Netherlands, and also volunteered to help with this study.