Study concept and design: Szummer, Oldgren, Carrero, Evans, Edfors, Andell, Jernberg.
Acquisition, analysis, or interpretation of data: Oldgren, Lindhagen, Carrero, Evans, Spaak, Jacobson, Andell, Wallentin, Jernberg.
Drafting of the manuscript: Szummer, Lindhagen, Carrero, Edfors.
Critical revision of the manuscript for important intellectual content: Szummer, Oldgren, Lindhagen, Carrero, Evans, Spaak, Jacobson, Andell, Wallentin, Jernberg.
Statistical analysis: Lindhagen.
Obtained funding: Jernberg.
Administrative, technical, or material support: Jacobson, Jernberg.
Study supervision: Wallentin, Jernberg.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Jernberg reports consulting for and receiving lecture fees from AstraZeneca. Dr Szummer reports receiving lecture fees from AstraZeneca. Dr Oldgren reports receiving consulting and lecture fees from Bayer, Boehringer Ingelheim, Bristol-Myers Squibb, and Pfizer. Dr Evans reports receiving payment for lectures for Amgen. Dr Spaak reports receiving grant funding from AbbVie; payment for lectures from Abbot and Merck; payment for the development of educational presentations from MSD; travel accommodations from Medtronic; and receiving support from the Karolinska Cardiorenal Theme Center. Dr Jacobson reports receiving support from the Karolinska Cardiorenal Theme Center and payment for lectures from Amgen and Fresenius Medical Care. Dr Wallentin reports receiving research grants from AstraZeneca, Merck & Co, Boehringer Ingelheim, Bristol-Myers Squibb/Pfizer, and GlaxoSmithKline; serving as a consultant for Abbott, Merck & Co, Regado Biosciences, Athera Biotechnologies, Boehringer Ingelheim, AstraZeneca, GlaxoSmithKline, and Bristol-Myers Squibb/Pfizer; lecture fees from AstraZeneca, Boehringer Ingelheim, Bristol-Myers Squibb/Pfizer, GlaxoSmithKline; honoraria from Boehringer Ingelheim, AstraZeneca, Bristol-Myers Squibb/Pfizer, GlaxoSmithKline; and travel support from AstraZeneca, Bristol-Myers Squibb/Pfizer, and GlaxoSmithKline. No other disclosures were reported.
Funding/Support: This work was supported by a grant from the Swedish Foundation for Strategic Research, the Swedish Heart and Lung Foundation, ALF Medicin (the regional agreement on medical training and clinical research between Stockholm County Council and Karolinska Institutet; Drs Szummer, Evans, Carrero), the Swedish Medical Research Council (Dr Carrero).
Role of the Funder/Sponsor: The funder was not involved in the design and conduct of the study; collection, management, analysis, or interpretation of the data; preparation, review, or approval of the manuscript; or decision to submit the manuscript for publication.
Correction: This article was corrected on February 19, 2015, to fix a typographical error in a subtitle.