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JAMA Clinical Guidelines Synopsis |

Use of Pneumococcal Vaccine in Adults

Jennifer Pisano, MD1; Adam S. Cifu, MD1
[+] Author Affiliations
1Department of Medicine, University of Chicago, Chicago, Illinois
JAMA. 2015;313(7):719-720. doi:10.1001/jama.2015.63.
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This JAMA Clinical Guidelines Synopsis article evaluates the most recent Advisory Committee for Immunization Practices guideline on use of 13-valent pneumococcal conjugate vaccine and 23-valent pneumococcal polysaccharide vaccine among adults aged 65 years or older.

Box Section Ref ID

Guideline title Use of 13-Valent Pneumococcal Conjugate Vaccine and 23-Valent Pneumococcal Polysaccharide Vaccine Among Adults Aged ≥65 Years

Developer Advisory Committee for Immunization Practices

Release date September 19, 2014

Prior version September 3, 2010

Funding source US Department of Health and Human Services

Target population Adults aged 65 years or older

Major recommendations

  • Pneumococcal vaccine–naive adults aged 65 years or older (or adults ≥65 years whose pneumococcal vaccine history is unknown) should receive 1 dose of 13-valent pneumococcal conjugate vaccine (PCV13) followed by a dose of 23-valent pneumococcal polysaccharide vaccine (PPSV23) 6 to 12 months later (minimum duration between PCV13 and PPSV23, 8 weeks).

  • Adults aged 65 years or older who have previously received 1 or more doses of PPSV23 should receive 1 dose of PCV13 1 year or longer after the most recent PPSV23 dose.

  • In adults who received PPSV23 before age 65 years, PCV13 should be given after age 65 years (and ≥1 year after the PPSV23 was given). PPSV23 should then be repeated 6 to 12 months later (and ≥5 years since the initial PPSV23 injection).

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