Author Contributions: Dr Manini had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Manini, Everhart, Harris.
Acquisition of data: Schoeller, Visser, Tylavsky, Harris.
Analysis and interpretation of data: Manini, Everhart, Patel, Schoeller, Colbert, Bauer, Goodpaster, Harris.
Drafting of the manuscript: Manini, Everhart, Harris.
Critical revision of the manuscript for important intellectual content: Everhart, Patel, Schoeller, Colbert, Visser, Tylavsky, Bauer, Goodpaster, Harris.
Statistical analysis: Manini, Everhart, Patel.
Obtained funding: Everhart, Harris.
Administrative, technical, or material support: Schoeller, Goodpaster, Harris.
Study supervision: Everhart, Harris.
Financial Disclosures: None reported.
Funding\Support: This research was supported by the Intramural Research Program of the National Institutes of Health, National Institute on Aging contracts N01-AG-6-2106, N01-AG-6-2101, and N01-AG-6-2103 with additional support from the National Institute of Diabetes and Digestive and Kidney Diseases.
Role of the Sponsor: The National Institute on Aging Intramural Research Program designed the Health ABC study, supervised its conduct, and participated in the data collection. The National Institute of Diabetes and Digestive and Kidney Diseases designed the energy expenditure substudy. The authors, the Health, Aging, and Body Composition (Health ABC) publications committee, and representatives from the National Institute on Aging reviewed and approved the manuscript.