Quitting smoking (smoking cessation) is one of the most important things you can do to improve your health and well-being. People who stop smoking decrease their risk of cancer, heart disease, stroke, and early death. Women who stop smoking before or during pregnancy reduce their risk of infertility or having a low-birth-weight baby. Most smokers in the United States report that they want to stop smoking, but kicking the smoking habit can be difficult. Most ex-smokers try several times, often as many as 8 to 10 times, before they are able to quit for good. The results are definitely worth those efforts. The July 5, 2006, issue of JAMA includes articles about varenicline, a new drug treatment aimed at helping patients to quit smoking and to remain smoke-free.