Author Contributions: Drs Bradley, Herrin, and Krumholz had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Bradley, Herrin, Elbel, McNamara, Magid, Spertus, Krumholz.
Acquisition of data: McNamara, Wang, Krumholz.
Analysis and interpretation of data: Bradley, Herrin, Elbel, McNamara, Magid, Nallamothu, Wang, Normand, Spertus, Krumholz.
Drafting of the manuscript: Bradley.
Critical revision of the manuscript for important intellectual content: Bradley, Herrin, Elbel, McNamara, Magid, Nallamothu, Wang, Normand, Spertus, Krumholz.
Statistical analysis: Bradley, Herrin, Normand.
Obtained funding: Krumholz.
Administrative, technical, or material support: Elbel.
Financial Disclosures: None reported.
Funding/Support: This research was supported by National Heart, Lung, and Blood Institute grant R01HL072575. Dr Bradley is supported by the Patrick and Catherine Weldon Donaghue Medical Research Foundation (grant 02-102) and a grant from the Claude D. Pepper Older Americans Independence Center at Yale (grant P30AG21342). Genentech Inc, provided access to the NRMI data.
Role of the Sponsor: None of the above sponsors had any role in the design and conduct of the study, the management, analysis and interpretation of the data, or the preparation and revision of the manuscript.
Acknowledgment: The article has benefited from comments from John Brush, MD, Cardiology Consultants Ltd, and Eastern Virginia Medical School, Norfolk, Va; Jeptha Curtis, MD, Yale University School of Medicine, New Haven, Conn; and Martha Blaney, PharmD, Genentech Inc, South San Francisco, Calif.