Author Contributions: Dr McTigue had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: McTigue, Kuller.
Acquisition of data: Valoski, Burke, Kotchen, Lewis, Stefanick, Van Horn, Kuller.
Analysis and interpretation of data: McTigue, Larson, Burke, Lewis, Stefanick, Kuller.
Drafting of the manuscript: McTigue, Larson, Valoski, Kotchen, Van Horn, Kuller.
Critical revision of the manuscript for important intellectual content: McTigue, Larson, Burke, Kotchen, Lewis, Stefanick, Kuller.
Statistical analysis: Larson, Kuller.
Obtained funding: Burke, Lewis, Stefanick, Kuller.
Administrative, technical, or material support: McTigue, Valoski, Kotchen, Lewis, Kuller.
Study supervision: Van Horn, Kuller.
Financial Disclosures: None reported.
Program Office: National Heart, Lung, and Blood Institute, Bethesda, Md: Barbara Alving, Jacques Rossouw, Shari Ludlam, Linda Pottern, Joan McGowan, Leslie Ford, and Nancy Geller.
Clinical Coordinating Center: Fred Hutchinson Cancer Research Center, Seattle, Wash: Ross Prentice, Garnet Anderson, Andrea LaCroix, Charles L. Kooperberg, Ruth E. Patterson, Anne McTiernan; Wake Forest University School of Medicine, Winston-Salem, NC: Sally Shumaker; Medical Research Labs, Highland Heights, Ky: Evan Stein; University of California, San Francisco, Steven Cummings.
Clinical Centers: Albert Einstein College of Medicine, Bronx, NY: Sylvia Wassertheil-Smoller; Baylor College of Medicine, Houston, Tex: Jennifer Hays; Brigham and Women's Hospital, Harvard Medical School, Boston, Mass: JoAnn Manson; Brown University, Providence, RI: Annlouise R. Assaf; Emory University, Atlanta, Ga: Lawrence Phillips; Fred Hutchinson Cancer Research Center, Seattle, Wash: Shirley Beresford; George Washington University Medical Center, Washington, DC: Judith Hsia; Harbor-UCLA Research and Education Institute, Torrance, Calif: Rowan Chlebowski; Kaiser Permanente Center for Health Research, Portland, Ore: Evelyn Whitlock; Kaiser Permanente Division of Research, Oakland, Calif: Bette Caan; Medical College of Wisconsin, Milwaukee: Jane Morley Kotchen; MedStar Research Institute/Howard University, Washington, DC: Barbara V. Howard; Northwestern University, Chicago, Ill: Linda Van Horn; Rush Medical Center, Chicago, Ill: Henry Black; Stanford Prevention Research Center, Stanford, Calif: Marcia L. Stefanick; State University of New York at Stony Brook, Stony Brook: Dorothy Lane; Ohio State University, Columbus: Rebecca Jackson; University of Alabama at Birmingham, Birmingham: Cora E. Lewis; University of Arizona, Phoenix: Tamsen Bassford; University at Buffalo, the State University of New York, Buffalo: Jean Wactawski-Wende; University of California at Davis, Sacramento: John Robbins; University of California at Irvine, Irvine: F. Allan Hubbell; University of California at Los Angeles, Los Angeles: Howard Judd; University of California at San Diego, LaJolla: Robert D. Langer; University of Cincinnati, Cincinnati, Ohio: Margery Gass; University of Florida, Gainesville: Marian Limacher; University of Hawaii, Honolulu: David Curb; University of Iowa, Iowa City: Robert Wallace; University of Massachusetts and Fallon Clinic, Worcester: Judith Ockene; University of Medicine and Dentistry of New Jersey, Newark: Norman Lasser; University of Miami, Miami, Fla: Mary Jo O’Sullivan; University of Minnesota, Minneapolis: Karen Margolis; University of Nevada, Reno: Robert Brunner; University of North Carolina, Chapel Hill: Gerardo Heiss; University of Pittsburgh, Pittsburgh, Pa: Lewis Kuller; University of Tennessee, Memphis: Karen C. Johnson; University of Texas Health Science Center, San Antonio: Robert Brzyski; University of Wisconsin, Madison: Gloria E. Sarto; Wake Forest University School of Medicine, Winston-Salem, NC: Denise Bonds; Wayne State University School of Medicine/Hutzel Hospital, Detroit, Mich: Susan Hendrix.
Funding/Support: The Women's Health Initiative program is funded by the National Heart, Lung, and Blood Institute, US Department of Health and Human Services. Dr McTigue was supported by grant 1 K08 DK067192-01 from the National Institute of Diabetes and Digestive and Kidney Diseases.
Role of the Sponsor: The representatives of the National Heart, Lung, and Blood Institute played a role in the design and conduct of the study and management and interpretation of the data, as well as review of the manuscript. They played no role in the collection or analysis of the data or preparation or approval of the manuscript. Representatives of the National Institute of Diabetes and Digestive and Kidney Diseases did not play a role in the design or conduct of the study, collection, management, analysis, and interpretation of the data, or preparation, review, or approval of the manuscript.
Previous Presentation: An abstract of an earlier version of this analysis was presented as a poster at an American Heart Association meeting in spring of 2005. It was published in a Circulation supplement at the time.