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Comment & Response |

Proposed Shift in Screening for Breast Cancer—Reply

Mary-Claire King, PhD1; Amnon Lahad, MD, MPH2; Ephrat Levy-Lahad, MD3
[+] Author Affiliations
1Department of Medicine, University of Washington, Seattle
2Faculty of Medicine, Hebrew University Medical School, Jerusalem, Israel
3Medical Genetics Institute, Shaare Zedek Medical Center, Jerusalem, Israel
JAMA. 2015;313(5):525-526. doi:10.1001/jama.2014.17442.
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In Reply Drs Levine and Steinberg are concerned about the number of women to be screened and the risks and costs of population-based screening for mutations in BRCA1 and BRCA2. It is accepted that a healthy woman with severe family history of breast or ovarian cancer should be offered testing for actionable mutations in BRCA1 and BRCA2 because cancer risk to mutation carriers can be significantly reduced by surgical intervention.1,2


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February 3, 2015
Beverly Levine, PhD; Karen Steinberg, PhD
1Department of Social Sciences and Health Policy, Wake Forest University School of Medicine, Winston Salem, North Carolina
2Retired, Atlanta, Georgia
JAMA. 2015;313(5):525. doi:10.1001/jama.2014.17436.
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