Author Contributions: Dr McMurray had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: McMurray, Teerlink, Cotter, Bourge, Cleland, Jondeau, Krum, Metra, O’Connor, Torre-Amione, van Veldhuisen, Rainisio, Kobrin.
Acquisition of data: McMurray, Teerlink, Cotter, Bourge, Cleland, Jondeau, Krum, Parker, van Veldhuisen, Frey, Kobrin.
Analysis and interpretation of data: McMurray, Teerlink, Cotter, Cleland, Krum, Metra, O’Connor, Parker, van Veldhuisen, Lewsey, Rainisio, Kobrin.
Drafting of the manuscript: McMurray, Teerlink, Cotter, Cleland, Krum, Metra, O’Connor, Parker, van Veldhuisen.
Critical revision of the manuscript for important intellectual content: McMurray, Teerlink, Cotter, Bourge, Cleland, Jondeau, Krum, Metra, O’Connor, Torre-Amione, van Veldhuisen, Lewsey, Frey, Rainisio, Kobrin.
Statistical analysis: Teerlink, Cotter, Lewsey, Rainisio.
Obtained funding: McMurray.
Administrative, technical, or material support: Teerlink, Bourge, Cleland, Jondeau, Parker, van Veldhuisen, Frey.
Study supervision: McMurray, Teerlink, Cleland, Krum, Metra, O’Connor, Parker, Torre-Amione, van Veldhuisen.
Financial Disclosures: None reported.
Funding/Support: The VERITAS trials were funded by Actelion Ltd. Drs Frey, Rainisio, and Kobrin are employees of Actelion.
Role of the Sponsor: Actelion Ltd designed the trial in conjunction with the VERITAS steering committee and was responsible for collection and management of the study data; apart from review by Drs Frey and Kobrin, Actelion had no role in the preparation or approval of the manuscript.
Independent Statistical Analysis: The data were analyzed by the sponsor and by an independent statistician (Dr Lewsey). Dr Lewsey received a full copy of the entire data set and prespecified analytical plan; evaluated the analysis plan for appropriateness in terms of carrying out the study objectives; and conducted an independent statistical analysis on the full data set, using SAS version 9 (SAS Institute Inc). Dr Lewsey replicated the results presented in the Results section, tables, and figures of the article. There were several minor discrepancies, which were resolved with the sponsor's statistician, and the results of Dr Lewsey's analyses reflect those reported in the article. Compensation for Dr Lewsey was provided by the University of Glasgow Discretionary Research Fund.
VERITAS-1 Investigators: Richard Pacher, University of Vienna, Austria; Gunnar Jensen, Roskilde Amt Sygehus, Roskilde, Denmark; Karl Josef Osterziel, Campus Virchow-Klinikum, Medizinische Klinik mit Schwerpunkt Kardiologie, Berlin, Germany; Peter Hanrath, Medizinische Klinik I, Universitätsklinikum Aachen, Aachen, Germany; Burkert Pieske, Georg-August-Universität Göttingen, Göttingen, Germany; John Nanas, University of Athens, Greece; Guillaume Jondeau, Hopital Ambroise Pare, Boulogne, France; Francois Funck, Heart Failure Clinic C. H. Dubos, Pontoise, France; Gerald-Jose Roul, Hopitaux Universitaires de Strasbourg, Hopital Hautepierre, Strasbourg, France; Michel Galinier, CHU Rangueil, Toulouse, France; Lucas Liaudet, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland; Tiziano Moccetti, Cardio Centro Ticino, Lugano, Switzerland; Marco Maggiorini, University Hospital Zürich, Zürich, Switzerland; John Cleland, Hull Royal Infirmary, Kingston-upon-Hull, United Kingdom; Jatinder Dhawan, Scunthorpe General Hospital, Scunthorpe, United Kingdom; Theresa McDonagh and Mark Petrie, Glasgow Royal Infirmary, Glasgow, United Kingdom; Reuven Zimlichmann, Wolfson Medical Center, Holon, Israel; Gad Cotter, Assaf-Harofeh Medical Center, Zriffin, Israel; Basil S. Lewis, Carmel Medical Center, Haifa, Israel; Mohammed Omary, Nazareth Hopital EMMS, Nazareth, Israel; Leonardo Reisin, Barzilai Hospital, Ashkelon, Israel; Chaim Lotan, Hadassah Hospital, Jerusalem, Israel; Walentyna Mazurek, Katedra I Klinika Kardiologii AM, Wroclaw, Poland; Kalina Kawecka-Jaszcz, Collegium Medicum UJ, Krakow, Poland; Jacek Kubica, Samodzielny Publiczny Szpital, Bydgoszcz, Poland; Andrzej Rynkiewicz, Akademia Medyczna w Gdansku, Gdansk, Poland; Wieslawa Tracz, College of Medicine of Jagellonian University, Krakow, Poland; Jacek Gryzybowski, National Institute of Cardiology, Warsaw, Poland; John Parker, Mount Sinai Hospital, Toronto, Ontario, Canada; Gordon Moe, St Michael's Hospital, Toronto, Ontario, Canada; Anique Ducharme, Montreal Heart Institute, Montreal, Quebec, Canada; Haissam Haddad, Ottawa Heart Institute, Ottawa, Ontario, Canada; Serge Lepage, Hospital Fleurimont, Sherbrooke, Quebec, Canada; J. Dale Cannon, Sumter Medical Consultants, Sumter, South Carolina; Douglas Chapman, Heart Consultants, Omaha, Nebraska; Alan Maisel, VA San Diego Healthcare System, San Diego, California; Reynolds Delgado, Texas Heart Institute, Houston; Norma Keller, Bellevue Hospital, New York, New York; Bradley Weinberg, Indiana Heart Hospital, Indianapolis; Bramah Singh, VA Medical Center of West Los Angeles, Los Angeles, California; Lynne Wagoner, University Hospital, Cincinnati, Ohio; David O. Taylor, Cleveland Clinic Foundation, Cleveland, Ohio; Jalal Ghali, LSU Health Sciences Center, Shreveport, Louisiana; John Teerlink, Department of Veterans Affairs, San Francisco, California; Denise Hermann, UCSD Medical Center, San Diego, California; Biykem Bozkurt, Veterans Affairs Medical Center, Houston, Texas; T. Barry Levine, Heart Hospital at Allegheny General, Pittsburgh, Pennsylvania; Jose A. Talíaj, University of Alabama-Birmingham; Brack Hattler, Denver Veterans Affairs Medical Center, Denver, Colorado; Thomas Amidon, Medical Associates, Bellevue, Washington; Frances Johnson and John Giacomini, Palo Alto VA Healthcare System, Palo Alto, California; Thadius Tolleson, Tyler Cardiovascular Consultants, Tyler, Texas; Boshara Zakhary, Danville Medical Center, Danville, Virginia.
VERITAS-2 Investigators: Karl Stangl, Universitätsklinikum der Humboldt-Universität Berlin, Berlin, Germany; Stephan B. Felix, Universität Greifswald, Greifswald, Germany; Christian Hengstenberg, Klinik u. Poliklinik f. Inn. Med. II, Regensburg, Germany; Hans-Georg Olbrich, Asklepios Klinik Langen, Langen, Germany; Franz Hartmann, Universitätsklinikum Schleswig Holstein, Lübeck, Germany; Livio Dei Cas and Marco Metra, Cattedra di Cardiologia, Brescia, Italy; Dan Atar, Aker University Hospital, Oslo, Norway; Kenneth Dickstein, Central Hospital in Rogaland, Stavanger, Norway; Torstein Hole, Sentralsykehuset I More og Romsdal, Alesund, Norway; Edoardo Gronda, Istituto Clinico Humanitas, Rozzano, Italy; John McMurray, University of Glasgow West, Glasgow, United Kingdom; Iain Squire, University of Leicester, Leicester, United Kingdom; Robert MacFayden, City Hospital, Birmingham, United Kingdom; M. A. Memon, Bridlington & District Hospital, Bridlington, United Kingdom; Roxy Senior, Northwick Park Hospital, Harrow, United Kingdom; Edo Kaluski, Assaf-Harofe Hospital, Zriffin, Israel; Doron Zahger, Soroka University Medical Center, Beer-Sheva, Israel; Alon Marmor, Rebecca-Zieff Medical Center, Safed, Israel; Abraham Caspi, Kaplan Hospital, Rehovot, Israel; N. Rougin, Western Galilee Hospital, Nahariya, Israel; Teddy Abraham Weiss, Hadassah University Hospital, Jerusalem, Israel; Dov Gavish, E. Wolfson Medical Center, Holon, Israel; D. J. van Veldhuisen, University Hospital Groningen, Groningen, the Netherlands; P.M. Landsaat‡ and J. P. R. Hermann, OLVG, Cardio Research, Amsterdam, the Netherlands; G. L. Bartels, Cardio Research Noord bv, Groningen, the Netherlands; H. R. Michels, Catharina Ziekenhuis Eindhoven, Eindhoven, the Netherlands; B. J. W. M. Rensing, Stichting Sint Antonius Ziekenhuis, Nieuwegein, the Netherlands; Duc Nam Nguyen, Akademisch Ziekenhuis, Brussels, Belgium; Martin Herold, University Hospital Vinohrady, Prague, Czech Republic; Bronislav Janek, Klinika Kardiologie IKEM, Prague, Czech Republic; Miroslav Soucek, Faculty Hospital St Anna, Brno, Czech Republic; Frantisek Holm, Krajska Nemocnice Liberec, Liberec, Czech Republic; Iveta Petrova, Masaryk Hospital, Usti nad Labem, Czech Republic; István Édes, University of Debrecen, Debrecen, Hungary; Tamás Forster, 2nd Department of Medicine & Cardiology Centre, Szeged, Hungary; György Sallai, Delpesti Korhaz, Budapest, Hungary; Janos Tomcsányi, Polyclinic of the Hospitaler Brothers of St John of God, Budapest, Hungary; Henry Krum, Monash University and Alfred Hospital, Prahran, Victoria, Australia; John Horowitz, Queen Elizabeth Hospital, Woodville, South Australia, Australia; Andrew Sindone, Concord Repatriation Hospital, Concord, New South Wales, Australia; Bleakley Chandler, University Hospital, Augusta, Georgia; David Rubinstein, Elmhurst Hospital Center, Elmhurst, New York; Uri Elkayam, LA County-USC Medical Center, Los Angeles, California; Ron Oren, University of Iowa Hospital and Clinics, Iowa City; Rafael Sequeira, University of Miami-Jackson Memorial Hospital, Miami, Florida; Monica Shah and Christopher O’Connor, Duke University Medical Center, Durham, North Carolina; Guillermo Torre, Baylor College of Medicine, Houston, Texas; Ignatius Thomas, Medical Research Institute, Slidell, Louisiana; Deborah Ascheim, Heart Failure Center at Columbia Presbyterian Medical Center, New York, New York; Kirkwood Adams, University of North Carolina, Chapel Hill; Jake Hochrein, LeBauer Cardiovascular Research Foundation, Greensboro, North Carolina; Michael J. Koren, Jacksonville Center for Clinical Research, Jacksonville, Florida; Mara T. Slawsky, Baystate Medical Center, Springfield, Massachusetts; Ulrich P. Jorde, New York University School of Medicine, New York; W. Herbert Haught, Oracle Research, Huntsville, Alabama; Daniel J. Lenihan, M.D. Anderson Cancer Center, Houston, Texas.