Author Contributions: Dr Pichichero had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Pichichero, Casey.
Acquisition of data: Pichichero, Casey.
Analysis and interpretation of data: Pichichero, Casey.
Drafting of the manuscript: Pichichero, Casey.
Statistical analysis: Pichichero, Casey.
Obtained funding: Pichichero.
Study supervision: Pichichero.
Financial Disclosures: Drs Pichichero and Casey report that they have received support from Ortho-McNeil, a division of Johnson and Johnson, the company that produces levofloxacin, for conducting clinical trials in children with otitis media, and that they have received compensation for consulting, speaking, and conducting clinical trials involving vaccines and antibiotics from multiple companies, including Abbott, Advancis, Bristol-Myers Squibb, GlaxoSmithKline, Innovia Medical, Johnson and Johnson, Medimmune, Merck, Replidyne, Sanofi Pasteur, Shionogi USA, Welch Allyn, and Wyeth.
Funding/Support: This study was supported by the Thrasher Research Foundation, Salt Lake City, Utah, and by a research grant from Abbott Laboratories, Abbott Park, Illinois.
Role of the Sponsors: The sponsors had no role in the study design or implementation, interpretation of data, analysis, or manuscript preparation.
Additional Contributions: Multilocus serotyping was performed by Qingfu Xu, DVM, PhD, Department of Microbiology/Immunology, University of Rochester Medical Center. Antibiotic susceptibility testing was performed in the laboratory of Gary Doern, PhD, University of Iowa, as a courtesy to Dr Pichichero; no compensation was provided.