Group Information: The Randomized Evaluation of Sedation Titration for Respiratory Failure (RESTORE) study investigators are listed in Supplement 1.
Published Online: January 20, 2015. doi:10.1001/jama.2014.18399.
Study concept and design: Curley, Wypij, Watson, Dodson, Franck, Gedeit, Angus, Matthay.
Acquisition, analysis, or interpretation of data: Curley, Wypij, Watson, Grant, Asaro, Cheifetz, Franck, Angus, Matthay.
Drafting of the manuscript: Curley, Wypij, Watson, Asaro, Franck, Matthay.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Wypij, Asaro.
Obtained funding: Curley, Wypij.
Administrative, technical, or material support: Curley, Grant, Cheifetz, Dodson, Franck, Gedeit, Angus, Matthay.
Study supervision: Curley, Wypij, Watson, Asaro.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Cheifetz reports personal fees for serving as a medical advisor for Philips. Dr Matthay reports personal fees for serving as chair of a data and safety monitoring board for Roche-Genentech and as a consultant for Cerus, Quark Pharmaceuticals, Biogen, and GlaxoSmithKline. No other disclosures were reported.
Funding/Support: This study was supported by grants from the National Heart, Lung, and Blood Institute and the National Institute of Nursing Research, National Institutes of Health (grant U01 HL086622 to Dr Curley and grant U01 HL086649 to Dr Wypij).
Role of the Funder/Sponsor: The study funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; or decision to submit the manuscript for publication.
Disclaimer: Dr Angus, JAMA Associate Editor, was not involved in the review of or decision to publish this article.
Additional Contributions are listed in Supplement 1.