Study concept and design: Corrales-Medina, Angus, Chirinos, Newman, Loehr, Yende.
Acquisition, analysis, or interpretation of data: Alvarez, Weissfeld, Chirinos, Chang, Newman, Loehr, Folsom, Elkind, Lyles, Kronmal, Yende.
Drafting of the manuscript: Corrales-Medina, Alvarez, Yende.
Critical revision of the manuscript for important intellectual content: Weissfeld, Angus, Chirinos, Chang, Newman, Loehr, Folsom, Elkind, Lyles, Kronmal, Yende.
Statistical analysis: Alvarez, Weissfeld, Chang, Loehr, Yende.
Obtained funding: Newman, Yende.
Administrative, technical, or material support: Kronmal, Yende.
Study supervision: Corrales-Medina, Angus, Chirinos, Yende.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Angus reports grant funding from the National Institutes of Health. Dr Elkind reports consulting for Biogen Idec, Bristol-Myers Squibb/Pfizer, Boehringer Ingelheim, Daiichi Sankyo, and Janssen; giving expert testimony for Merck/Organon; serving on the advisory board for CardioNet; and receiving grant funding from Bristol-Myers Squibb/Sanofi and diaDexus. No other disclosures were reported.
Funding/Support: The Cardiovascular Health Study (CHS) was supported by contracts HHSN268201200036C, HHSN268200800007C, N01 HC55222, N01HC85079, N01HC85080, N01HC85081, N01HC85082, N01HC85083, N01HC85086, and grant HL080295 from the National Heart, Lung, and Blood Institute (NHLBI), with additional contribution from the National Institute of Neurological Disorders and Stroke (NINDS). Additional support was provided by grant AG023629 from the National Institute on Aging (NIA). A full list of principal CHS investigators and institutions can be found at CHS-NHLBI.org. The Atherosclerosis Risk in Communities study was supported by contracts HHSN268201100005C, HHSN268201100006C, HHSN268201100007C, HHSN268201100008C, HHSN268201100009C, HHSN268201100010C, HHSN268201100011C, and HHSN268201100012C from the NHLBI. This article is also supported by a Junior Investigator Award from the Department of Medicine of The Ottawa Hospital and the Ottawa Hospital Research Institute in Ottawa, Ontario, Canada (Dr Corrales-Medina) and by K23GM083215 and R01GM097471 from the National Institute of General Medical Sciences (Dr Yende).
Disclaimer: The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Dr Angus, a JAMA associate editor, had no role in the evaluation of or decision to publish this article.