Author Contributions: Drs Norris and Rewers had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Norris, Clare-Salzler, Rewers.
Acquisition of data: Norris, Lamb, Barriga, Seifert, Hoffman, Clare-Salzler, Szabo, Erlich, Eisenbarth.
Analysis and interpretation of data: Norris, Yin, Orton, Barón, Clare-Salzler, Chase, Szabo, Erlich.
Drafting of the manuscript: Norris, Seifert, Hoffman, Clare-Salzler.
Critical revision of the manuscript for important intellectual content: Yin, Lamb, Barriga, Hoffman, Orton, Barón, Clare-Salzler, Chase, Szabo, Erlich, Eisenbarth, Rewers.
Statistical analysis: Norris, Yin, Orton, Barón.
Obtained funding: Norris, Clare-Salzler, Rewers.
Administrative, technical, or material support: Lamb, Seifert, Clare-Salzler, Chase, Szabo, Erlich, Eisenbarth.
Study supervision: Norris, Barriga, Seifert, Hoffman, Eisenbarth, Rewers.
Financial Disclosures: None reported.
Funding/Support: This work was supported by grants R01-DK49654, DK32493, and P01-142288 from the National Institutes of Health, and P30 DK 57516 from the Diabetes Endocrine Research Center, Clinical Investigation and Bioinformatics Core.
Role of Sponsors: The funding sources did not participate in the design and conduct of the study, in the collection, analysis, and interpretation of the data, or in the preparation, review, or approval of the manuscript.
Additional Contributions: We thank the dedicated and talented staff of the DAISY study for their clinical, data, and laboratory support. We also thank all the children and their families who generously volunteered their time and knowledge.