In summary, after more than 60 years of experimenting with multiple mechanisms to support biomedical research, HHMI is focused on 4 key strategies for driving science forward. First, selecting and supporting people, not projects, which is the most effective mechanism to encourage model-shifting discoveries that invariably lead to better understanding of human disease and ultimately more effective treatments. Second, continuing to emphasize and support fundamental discovery research, which has proven to be the foundation of modern medicine. Too much about complex biological processes and human biology remains to be discovered, and more completely understood, to let up on this effort. Third, placing greater emphasis on supporting and encouraging the best students from many disparate fields of study and diverse backgrounds to seek a career in biomedical research—especially in this 21st century of biology. Fourth, crafting new ways to streamline the training of patient-oriented physician-scientists to increase the pipeline of next-generation biomedical researchers capable of forging strong links between fundamental biology discoveries and medicine.