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Comment & Response |

Reanalyses of Trial Results—Reply

Shanil Ebrahim, PhD1; John P. A. Ioannidis, MD, DSc1
[+] Author Affiliations
1Meta-Research Innovation Center at Stanford, Stanford University, Stanford, California
JAMA. 2015;313(1):93. doi:10.1001/jama.2014.15644.
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In Reply Drs Platts-Mills and Jones have raised a potential concern with the search strategy used in our study on reanalyses of randomized clinical trial data, specifically with respect to our restriction to studies indexed as a clinical trial publication type in MEDLINE. We agree with them that a strategy with no restriction to clinical trials publication type would be more sensitive in detecting reanalyses.

However, performing such a search would yield a total of 112 330 citations (limited to March 9, 2014, as per our original search). Screening this number of citations would be a daunting task and may not be a valuable use of resources if the output of additional studies retrieved would be few in number compared with the studies retrieved in our original search.


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January 6, 2015
Timothy F. Platts-Mills, MD, MSc; Christopher W. Jones, MD
1Department of Emergency Medicine, University of North Carolina, Chapel Hill
2Department of Emergency Medicine, Cooper Medical School of Rowan University, Camden, New Jersey
JAMA. 2015;313(1):92-93. doi:10.1001/jama.2014.15627.
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