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Comment & Response |

Risk Profile of Clinical Trial Participants—Reply

Jacob A. Udell, MD, MPH1; Matthew T. Roe, MD, MHS2; Stephen D. Wiviott, MD3
[+] Author Affiliations
1Women’s College Hospital, University of Toronto, Toronto, Ontario, Canada
2Duke Clinical Research Institute, Duke University, Durham, North Carolina
3Cardiovascular Division, Brigham and Women’s Hospital, Boston, Massachusetts
JAMA. 2015;313(1):94-95. doi:10.1001/jama.2014.15633.
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In Reply Dr Kostis and colleagues suggest that patients with myocardial infarction who participate in clinical trials may demonstrate even more pronounced differences in presenting factors, hospital care, and outcomes compared with patients included in the US Healthcare Cost and Utilization Project Nationwide Inpatient Sample. Although such a comparison could potentially bolster our findings, we are not aware of data from the sample documenting clinical trial participation to allow for a valid comparison.1


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January 6, 2015
William J. Kostis, MD, PhD; Sri Ram Pentakota, MD, MPH, PhD; Abel E. Morerya, MD
1Cardiology Division, Massachusetts General Hospital, Boston
2Cardiovascular Institute, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey
JAMA. 2015;313(1):93-94. doi:10.1001/jama.2014.15630.
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