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Comment & Response |

Reanalyses of Trial Results

Timothy F. Platts-Mills, MD, MSc1; Christopher W. Jones, MD2
[+] Author Affiliations
1Department of Emergency Medicine, University of North Carolina, Chapel Hill
2Department of Emergency Medicine, Cooper Medical School of Rowan University, Camden, New Jersey
JAMA. 2015;313(1):92-93. doi:10.1001/jama.2014.15627.
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To the Editor We agree with Dr Ebrahim and colleagues1 that reanalyses of clinical trial data provide an important opportunity to better understand trial results and that more independent reanalyses are needed. However, the estimate of the number of reanalyses published prior to March 9, 2014, reported by Ebrahim et al1 is incorrect, possibly by a substantial margin.


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January 6, 2015
Shanil Ebrahim, PhD; John P. A. Ioannidis, MD, DSc
1Meta-Research Innovation Center at Stanford, Stanford University, Stanford, California
JAMA. 2015;313(1):93. doi:10.1001/jama.2014.15644.
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