0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Lab Reports |

Structural Analysis of Antibodies in Ebola Treatment

Tracy Hampton, PhD
JAMA. 2015;313(1):20. doi:10.1001/jama.2014.16897.
Text Size: A A A
Published online

Extract

The experimental Ebola treatment ZMapp, administered to several infected individuals during the ongoing epidemic, contains key components of 2 antibody mixtures (MB-003 and ZMab) whose mechanisms of action have remained unclear. Through the use of single-particle electron microscopy, Scripps Research Institute investigators and their colleagues have determined the structure of each antibody in ZMapp, as well as additional antibodies from MB-003 and ZMab cocktails from which ZMapp was derived, bound to the Ebola virus surface glycoprotein (Murin CD et al. Proc Natl Acad Sci U S A. doi:10.1073/pnas.1414164111 [published online November 17, 2014]).

Figures in this Article

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview

Figures

Place holder to copy figure label and caption

Graphic Jump LocationImage not available.

Structural analysis of antibodies in the experimental Ebola treatment ZMapp reveals sites of viral vulnerability.

National Institute of Allergy and Infectious Diseases/Centers for Disease Control and Prevention

Tables

References

CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

504 Views
0 Citations
×

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Collections
PubMed Articles
Jobs
brightcove.createExperiences();