Author Contributions: Drs Danesh and Di Angelantonio had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Bennet, Di Angelantonio, Wiman, de Faire, Danesh.
Acquisition of data: Bennet, Di Angelantonio, Ye, Wensley, Dahlin, Keavney, Collins, Wiman, de Faire, Danesh.
Analysis and interpretation of data: Bennet, Di Angelantonio, Wensley, Keavney, Collins, Wiman, de Faire, Danesh.
Drafting of the manuscript: Bennet, Di Angelantonio, Danesh.
Critical revision of the manuscript for important intellectual content: Bennet, Di Angelantonio, Ye, Wensley, Dahlin, Ahlbom, Keavney, Collins, Wiman, de Faire, Danesh.
Statistical analysis: Bennet, Di Angelantonio, Wensley.
Obtained funding: de Faire, Danesh.
Administrative, technical, or material support: Bennet, Di Angelantonio, Ye, Dahlin, Wiman, de Faire, Danesh.
Study supervision: Bennet, Wiman, de Faire, Danesh.
Drs Bennet and Di Angelantonio are joint first authors.
Financial Disclosures: None reported.
Funding/Support: This work was supported by the British Heart Foundation, an unrestricted educational grant from GlaxoSmithKline, the Raymond and Beverly Sackler Award in the Medical Sciences, Swedish Research Council (grant 05193), the Swedish Heart and Lung Foundation (grant 199941395 and 200041272), Wallenberg Consortium North, the King Gustaf V, and Queen Victoria's Foundation.
Role of the Sponsor: The sponsors had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; or preparation, review, or approval of the manuscript.
Additional Contributions: The following investigators kindly provided additional information from their studies: Xiaojuan Bai, MD, China Medical University, China; Virginia Baňares, MD, Laboratorio de Genetica Molecular, Buenos Aires, Argentina; Elisabeth Barrett-Connor, MD, University of California San Diego; Petr Benes, MD, Faculty of Science, Masaryk University, Czech Republic; Maurizio Cassader, MD, University of Turin, Italy; Juliana Chan, MD, Chinese University of Hong Kong, China; Eliecer Coto, MD, Hospital Central de Asturias, Spain; Roberto Corrocher, MD, University of Verona, Italy; Patrick Couture, MD, Laval University, Quebec City, Quebec; John Crouse, MD, Wake Forest University School of Medicine, Winston-Salem, North Carolina; Anthony Dart, MD, Baker Heart Research Institute, Melbourne, Australia; Jean Davignon, MD, Clinical Research Institute of Montreal, Montreal, Quebec; Janneke Dijck-Brouwer, MD, University Medical Center Groningen, Groningen, the Netherlands; Luc Djoussé, MD, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; Cornelia van Duijn, MD, Erasmus Medical Center, Rotterdam, the Netherlands; Nduna Dzimiri, MD, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia; Shuzhi Feng, MD, Tianjin Medical University Hospital, Tianjin, China; Jean Ferrières, MD, Faculté de Médecine, Toulouse, France; Aaron Folsom, MD, School of Public Health, University of Minnesota, Minneapolis; Aidil Fonseca, MD, Instituto Nacional de Saúde, Lisboa, Portugal; Ruth Frikke-Schmidt, MD, Copenhagen University Hospital, Copenhagen, Denmark; Carmen Garces, MD, Universidad Autonoma de Madrid, Madrid, Spain; Ulrik Gerdes, MD, University Psychiatric Hospital in Aarhus, Risskov, Denmark; Bas Heijmans, MD, Leiden University Medical Centre, Leiden, the Netherlands; Gülay Hergenc, MD, Turkish Society of Cardiology, Istanbul, Turkey; Barbara Howard, MD, MedStar Research Institute, Washington, DC; Aida Inbal, MD, Tel-Aviv University, Tel-Aviv, Israel; Aaron Isaacs, MD, Erasmus Medical Center, Rotterdam, the Netherlands; Turgay Isbir, MD, Istanbul University, Istanbul, Turkey; Jorge Joven, MD, Hospital Universitari de Sant Joan, Reus, Spain; Tomohiro Katsuya, MD, Osaka University Graduate School of Medicine, Osaka, Japan; Genovefa Kolovou, MD, Onassis Cardiac Surgery Center, Athens, Greece; Edward Lakatta, MD, National Institute on Aging, Baltimore, Maryland; Federico Licastro, MD, Università di Bologna, Italy; Gérald Luc, MD, Université de Lille 2, Lille, France; Kalpana Luthra, PhD, Institute of Medical Sciences, New Delhi, India; Antonio Mansur, MD, PhD, University of São Paulo Medical School, São Paulo, Brazil; Winfried März, MD, Synlab Centre of Laboratory Diagnostics, Heidelberg, Germany; Richard Mayeux, MD, Columbia University, New York, New York; Anoop Misra, MD, Institute of Medical Sciences, New Delhi, India; Maggie Ng, PhD, Chinese University of Hong Kong, Hong Kong, China; Viviane Nicaud, MD, Université Pierre et Marie Curie-Paris 6, Paris, France; Matthias Orth, MD, Ruhr-Univesitat, Bochum, Germany; Dao-Quan Peng, MD, PhD, Central South University, Changsha, China; Daniel Petrovič, MD, PhD, University of Ljubljana, Ljubljana, Slovenja; N. Ranjith, MD, University of Kwazulu-Natal, Durban, South Africa; Katarina Raslova, MD, Institute of Preventive and Clinical Medicine, Bratislava, Slovak Republic; Patrick Rump, MD, PhD, Maastricht University, Maastricht, the Netherlands; Nicole Schupf, PhD, Columbia University, New York, New York; José Sorli, MD, University of Valencia, Valencia, Spain; James Terry, MD, Wake Forest University, Winston-Salem, North Carolina; Laurance Tiret, PhD, INSERM U525, Université Pierre et Marie Curie, Paris, France; E. Shyong Tai, MD, Singapore General Hospital, Singapore; Daniel Chun-hang Wai, MD, Singapore General Hospital, Singapore; Yonghong Xie, MD, Fourth Military Medical University, Xi-an, China; Kimiko Yamakawa-Kobayashi, PhD, University of Tsukuba, Tsukuba-shi Ibaraki-ken, Japan; Shu Ye, MD, PhD, William Harvey Research Institute, London, England; Iwona Zak, MD, Medical University of Silesia, Katowice, Poland; Dian-Wen Zhang, MD, Qingdao Hiserver Hospital, Qingdao, China; Jianhua Zhu, MD, Affiliated Hospital of Nantong Medical College, Nantong, China; Martin Bobrow, FRS, University of Cambridge, Cambridge, England; and Adam Butterworth, MSc, Cambridge Genetics Knowledge Park, Cambridge, England commented helpfully. Elena Zotova, BA, Albert Einstein College of Medicine, Bronx, New York, helped with translation of reports published in Russian. None of these individuals received compensation.