Author Contributions: Ms Zuckerman had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Zuckerman, Lahad, Zimran, Levy-Lahad, Sagi.
Acquisition of data: Zuckerman, Zimran, Peleg, Orr-Urtreger, Sagi.
Analysis and interpretation of data: Zuckerman, Lahad, Shmueli, Levy-Lahad, Sagi.
Drafting of the manuscript: Zuckerman, Shmueli, Levy-Lahad, Sagi.
Critical revision of the manuscript for important intellectual content: Zuckerman, Lahad, Shmueli, Zimran, Peleg, Orr-Urtreger, Levy-Lahad, Sagi.
Statistical analysis: Zuckerman, Lahad.
Obtained funding: Zimran, Levy-Lahad.
Administrative, technical, or material support: Zuckerman, Zimran, Levy-Lahad.
Study supervision: Levy-Lahad, Sagi.
Financial Disclosures: Dr Zimran reported receiving consulting fees from Shire Human Genetic Therapeutics and Protalix Biopharmaceutics, receiving a grant from Genzyme Corporation for participation in the International Gaucher Registry, and receiving honoraria from Genzyme Corporation and Actelion. He also reported holding Protalix Biopharmaceutics stock options. None of the other authors reported financial disclosures.
Funding/Support: This study was funded by the Israel Institute for Health Policy and Health Services Research.
Role of Sponsor: The Israel Institute for Health Policy and Health Services Research had no role in the design and conduct of the study, in the collection, management, analysis, or interpretation of the data, or in the preparation, review, or approval of the manuscript.
Previous Presentation: Presented as a poster (abstract 1210) at the American Society of Human Genetics Meeting; October 28, 2005; Salt Lake City, Utah.
Additional Contributions: We thank all participating couples, and express our gratitude to the following Genetic Counselors and Medical Geneticists who assisted, without receiving compensation, in data collection for this study: Lilach Peled-Peretz, MSc, Haemek Medical Center, Afula; Yulia Grinshpun-Cohen, MSc, and Atalia Shtorch-Asor, PhD, Meir Medical Center, Kfar Saba; Vardit Adir, PhD, and Zvi Borochovich, MD, Bnai Zion Medical Center, Haifa; Marsha Zeigler, PhD, and Avital Eilat, MSc, Hadassah Hebrew University Hospital, Jerusalem; Sharon Simchoni, MSc, and Yuval Yaron, MD, Tel Aviv Sourasky Medical Center, Tel Aviv; Ellen Taub, MSc, Rabin Medical Center, Petah-Tikvah; Vitalia Libman, MSc, Assaf Harofeh Medical Center, Zerifin; and Amalia Shaham, Carmel Medical Center, Haifa. Hadassa Hartman, BSc, Medical Genetics Unit, Shaare Zedek Medical Center, provided help in preparing the manuscript. Ms Hartman is a paid employee at Shaare Zedek Medical Center.