Author Contributions: Dr Lincoff had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Lincoff, Wolski, Nissen.
Acquisition of data: Lincoff, Wolski, Nissen.
Analysis and interpretation of data: Lincoff, Wolski, Nicholls, Nissen.
Drafting of the manuscript: Lincoff, Nissen.
Critical revision of the manuscript for important intellectual content: Lincoff, Wolski, Nicholls, Nissen.
Statistical analysis: Lincoff, Wolski, Nicholls, Nissen.
Obtained funding: Nissen.
Administrative, technical, or material support: Nissen.
Study supervision: Lincoff.
Financial Disclosures: Drs Lincoff and Nissen report receiving research support to perform clinical trials through the Cleveland Clinic Cardiovascular Coordinating Center from Takeda, Sanofi-Aventis, Eli Lilly, Pfizer, Centocor, Dr Reddy's Laboratory, Medicines Company, Roche, Daiichi-Sankyo, Schering-Plough, Scios, and AstraZeneca. Drs Lincoff and Nissen provide consulting for a number of pharmaceutical companies, but require them to donate all honoraria or consulting fees directly to charity so that they receive neither income nor tax deductions. Dr Nicholls reports receiving honoraria and consulting fees from Takeda, Pfizer, AstraZeneca, Novo-Nordisk, Merck Schering-Plough, Roche, and Anthera.
Funding/Support: This study was funded by a $25 000 grant from Takeda Pharma to support the statistical analyses.
Role of the Sponsor: The company had been involved in the collection of data for the original trials used for this meta-analysis and participated in the identification of adverse events from records within their database. The company provided that database of eligible trials to the Cleveland Clinic, and did not participate in the statistical analyses used for this publication. The company was not involved in preparing the manuscript and was not permitted to review or comment on the contents.
Additional Contribution: We gratefully acknowledge the assistance of Suzanne Turner, BA, Department of Cardiovascular Medicine, Cleveland Clinic, in creating the figures for this article. Ms Turner received no compensation for her work in association with this article.