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Editorial |

Cardiovascular Risk and the Thiazolidinediones:  Déjà Vu All Over Again?

Daniel H. Solomon, MD, MPH; Wolfgang C. Winkelmayer, MD, ScD
JAMA. 2007;298(10):1216-1218. doi:10.1001/jama.298.10.1216.
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In 2005, the US Food and Drug Administration (FDA) held an advisory committee meeting to help determine the safety of selective cyclooxygenase 2 (COX-2) inhibitors, a popular group of drugs with a novel mechanism of action but with incompletely understood effects on the cardiovascular system. Although these drugs have some potential benefits with respect to gastrointestinal toxic effects, their benefit-risk ratio was and is still unclear. Fast forward 2 years to 2007, and the FDA held a similar advisory committee meeting about the safety of rosiglitazone, a widely used thiazolidinedione (TZD) with known benefits on glycemic control but potential cardiovascular toxic effects. What have clinicians, patients, and the public learned through these recent events?

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