In West Africa, a proactive response should include several key elements. First, a rapid assessment of outbreak-associated psychological stressors, for both civilians and health care workers, is needed. One option is to use trauma signature analysis, an evidence-based method that assesses a population exposure to an extreme event, providing actionable guidance for highly targeted support programs.7 Trauma signature analysis, which previously has been used in a series of major disasters, including the 2011 Japan tsunami,8 aims to identify unique characteristics of an event, create a hazard profile, enumerate event-specific stressors, and estimate the severity of exposure and related psychological risk factors. Second, an intervention, consistent with the Inter-Agency Standing Committee (IASC) guidelines on mental health and psychosocial support in emergency settings,9 and adapted to the unique features of the Ebola virus outbreak, is needed to be rapidly implemented and maintained throughout the recovery process. The IASC guidelines are organized around a 4-tiered intervention pyramid: (1) restoring basic services and security for the affected population, (2) strengthening family and community networks, (3) providing distressed individuals with psychosocial support, and (4) providing specialized mental health intervention for severely affected survivors.9 Such a system of support has been previously used for Syrian war refugees, Philippine typhoon survivors, and Nepalese survivors of political violence. Third, the intervention should specifically target high-risk subpopulations such as stigmatized survivors, bereaved family members, ostracized orphans, and health care and burial workers who have witnessed extreme morbidity and mortality.