Author Contributions: Dr Singh had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Singh, Shishehbor, Ansell.
Acquisition of data: Singh, Shishehbor.
Analysis and interpretation of data: Singh, Shishehbor, Ansell.
Drafting of the manuscript: Singh, Shishehbor, Ansell.
Critical revision of the manuscript for important intellectual content: Singh, Shishehbor, Ansell.
Administrative, technical, or material support: Singh, Shishehbor, Ansell.
Study supervision: Shishehbor, Ansell.
Dr Singh and Dr Shishehbor contributed equally to this manuscript.
Financial Disclosures: Dr Ansell reported receiving speaking honoraria from AstraZeneca, Kos Pharmaceuticals, Merck, and Pfizer; receiving research medication from Merck and Pfizer in the past; and having equity interest in Bruin Pharma. No other disclosures were reported.
Funding/Support: Dr Shishehbor is supported in part by the National Institutes of Health, National Institute of Child Health and Human Development, Multidisciplinary Clinical Research Career Development Programs grant K12 HD049091 and the National Institutes of Health Loan Repayment Program. Dr Ansell is supported by private philanthropy from Mr and Mrs Timothy Hannemann, Ms Kathleen Kennedy, Mr Frank Marshall, Mr and Mrs Michael Ovitz, and Mr and Mrs Nelson Rising.
Role of the Sponsor: Neither the National Institutes of Health nor any of the individuals supporting Dr Ansell through philanthropy had any role in the design and conduct of the study; the collection, analysis, and interpretation of the data; or the preparation, review, or approval of the manuscript.
Additional Contributions: Alan M. Fogelman, MD (Department of Medicine and Atherosclerosis Research Unit, University of California, Los Angeles), provided thorough and helpful criticisms of the manuscript, and Dave Schumick, BS, CMI (Center for Medical Art and Photography, Cleveland Clinic, Cleveland, Ohio), provided assistance with the figures. Neither received compensation for their contributions.