Author Contributions: Drs Schousboe and Taylor had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Schousboe, Kane.
Acquisition of data: Schousboe, Cummings, Orwoll, Melton, Ensrud.
Analysis and interpretation of data: Schousboe, Taylor, Fink, Cummings, Orwoll, Melton, Bauer, Ensrud.
Drafting of the manuscript: Schousboe.
Critical revision of the manuscript for important intellectual content: Schousboe, Taylor, Fink, Kane, Cummings, Orwoll, Melton, Bauer, Ensrud.
Statistical analysis: Schousboe, Taylor, Fink.
Obtained funding: Cummings, Orwoll, Ensrud.
Administrative, technical, or material support: Taylor, Orwoll.
Study supervision: Kane.
Financial Disclosures: Dr Schousboe reports receiving research support from Hologic Inc and serving as a consultant to Eli Lilly, Merck, and Amgen. Dr Bauer reports receiving research support from Novartis, Amgen, Procter & Gamble, and Merck. Dr Cummings reports receiving research support from Amgen, Novartis, Pfizer, Lilly, and Zelos and serving as a consultant to or receiving honoraria from Novartis, Pfizer, Lilly, and Merck. Dr Orwoll reports receiving research support from Aventis, Pfizer, Lilly, Novartis, Procter & Gamble, GlaxoSmithKline, Solvay, Zelos, and Amgen and receiving honoraria from Merck. Dr Ensrud reports receiving research support from Bionovo, Eli Lilly, and Pfizer. No other disclosures were reported.
Funding/Support: The MrOS study, which was used to derive certain model parameters, is supported by National Institutes of Health funding under the following grant numbers: National Institute of Arthritis and Musculoskeletal and Skin Diseases: U01 AR45580, U01 AR45614, U01 AR45632, U01 AR45647, U01 AR45654, U01 AR45583; National Institute on Aging: U01 AG18197, U01-AG027810; and National Center for Research Resources: UL1 RR024140.
Role of the Sponsor: The funding agencies had no role in the design and conduct of the study, in the collection, analysis, and interpretation of the data, or in the preparation, review, or approval of the manuscript.