Author Contributions: Dr Peterson had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Glickman, Roe, Gibler, Ohman, Peterson.
Acquisition of data: Glickman, Roe, Lytle, Peterson.
Analysis and interpretation of data: Glickman, Ou, DeLong, Roe, Mulgund, Rumsfeld, Schulman, Peterson.
Drafting of the manuscript: Glickman, Peterson.
Critical revision of the manuscript for important intellectual content: Glickman, Ou, DeLong, Roe, Lytle, Mulgund, Rumsfeld, Gibler, Ohman, Schulman, Peterson.
Statistical analysis: Glickman, Ou, DeLong, Mulgund, Peterson.
Obtained funding: Roe, Gibler, Ohman, Peterson.
Administrative, technical, or material support: Roe, Lytle, Gibler, Ohman, Schulman, Peterson.
Study supervision: Schulman, Peterson.
Financial Disclosures: Dr Roe reports receiving speakers' bureau honoraria from Millennium Pharmaceuticals Inc, Bristol-Myers Squibb/Sanofi Pharmaceuticals Partnership, and Schering Corp and research grants from Millennium Pharmaceuticals Inc, Bristol-Myers Squibb/Sanofi-Aventis Pharmaceuticals Partnership, and Schering Corp. Dr Rumsfeld reports that he serves on the scientific advisory board for United Healthcare and is chief science officer for the American College of Cardiology National Cardiovascular Data Registries. Dr Gibler reports receiving research grants from Millennium Pharmaceuticals Inc, Schering Corp, and Bristol-Myers Squibb/Sanofi Pharmaceuticals Partnership. Dr Ohman reports receiving research grants from Millennium Pharmaceuticals Inc, Bristol-Myers Squibb/Sanofi Pharmaceuticals Partnership, Schering Corp, and Berlex. Drs Schulman and Peterson have made available detailed listings of disclosure information at: http://www.dcri.duke.edu/research/coi.jsp. No other authors reported financial disclosures.
Funding/Support: Bristol-Myers Squibb/Sanofi Pharmaceuticals Partnership provided additional funding support. Millennium Pharmaceuticals Inc also funded this work. Dr Peterson is also the recipient of grant R01 AG025312 01A1 from the National Institute on Aging. CRUSADE is funded by the Schering-Plough Corp.
Role of the Sponsor: Although none of the sponsors were directly involved in design and conduct of the study, in the collection, management, analysis, and interpretation of the data, or preparation of the manuscript, the sponsors all reviewed the submitted manuscript. Dr Glickman’s role in this research was made possible by a gift from the Douglas and Stefanie Kahn Charitable Gift Fund.
Acknowledgment: CRUSADE is a National Quality Improvement Initiative of the Duke Clinical Research Institute.