Published Online: June 3, 2007 (doi:10.1001/jama.297.21.2360).
Author Contributions: Dr Huntsman had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Kaurah, Senz, Pizzuti, Ford, Huntsman.
Acquisition of data: Kaurah, MacMillan, Senz, De Luca, Chun, Suriano, Zaor, Manen, Gilpin, Nikkel, Connolly-Wilson, Weissman, Rubinstein, Sebold, Greenstein, Stroop, Yim, Panzini, McKinnon, Greenblatt, Fontaine, Coit, Yoon, Chung, Lauwers, Vaccaro, Redal, Oliveira, Tischkawitz, Olschwang, Gallinger, Lynch, Green, Ford, Fernandez, Huntsman.
Analysis and interpretation of data: Kaurah, Boyd, Senz, De Luca, Suriano, Wirtzfeld, Oliveira, Lynch, Ford, Pharoah, Huntsman.
Drafting of the manuscript: Kaurah, Boyd, Senz, De Luca, Yim, Pharoah, Huntsman.
Critical revision of the manuscript for important intellectual content: Kaurah, MacMillan, Boyd, De Luca, Chun, Suriano, Zaor, Manen, Gilpin, Nikkel, Connolly-Wilson, Weissman, Rubinstein, Sebold, Greenstein, Stroop, Panzini, McKinnon, Greenblatt, Wirtzfeld, Fontaine, Coit, Yoon, Chung, Lauwers, Pizzuti, Vaccaro, Redal, Oliveira, Tischkawitz, Olschwang, Gallinger, Lynch, Green, Ford, Pharoah, Fernandez.
Statistical analysis: Pharoah.
Obtained funding: Lynch, Huntsman.
Administrative, technical, or material support: Kaurah, MacMillan, Boyd, Senz, De Luca, Gilpin, Wirtzfeld, Fontaine, Chung, Lauwers, Pizzuti, Redal, Olschwang, Gallinger, Lynch.
Study supervision: Weissman, Rubinstein, Coit, Fernandez, Huntsman.
Financial Disclosures: At the time of data collection Ms Sebold was working within a US military hospital as an independent contractor. No other authors reported disclosures.
Funding/Support: This work was made possible through funding received from the National Cancer Institute of Canada grant 015227 (Dr Huntsman), revenue from Nebraska cigarette taxes awarded to Creighton University by the Nebraska Department of Health and Human Services (Dr Lynch), and by National Institutes of Health grant 5UO1 CA86389 (Dr Lynch). Dr Huntsman and Mr De Luca are Michael Smith Foundation for Health Research Scholars.
Role of the Sponsor: The funding agencies had no role in the design and conduct of the study, in the collection, analysis, and interpretation of the data, and in the preparation, review, or approval of the manuscript.
Disclaimer: The contents of this article are the sole responsibility of the authors and do not necessarily represent the official views of the State of Nebraska or the Nebraska Department of Health and Human Services.
Acknowledgment: We thank all the families and their caregivers for their willing participation in this research project and who provided consent regarding use of the information obtained from the study. We also thank the International Gastric Linkage Consortium for providing a forum for knowledge transfer and collaboration for the community of hereditary diffuse gastric cancer researchers. We also thank Graham Peacock for assistance in configuring the pedigree. He did this work as part of his paid summer student job.