Author Contributions: Dr Horstmann had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: May, Evans, Timmann, Agbenyega, Horstmann.
Acquisition of data: Evans, Timmann, Ehmen, Agbenyega, Horstmann.
Analysis and interpretation of data: May, Evans, Busch, Thye, Agbenyega, Horstmann.
Drafting of the manuscript: Horstmann.
Critical revision of the manuscript for important intellectual content: May, Evans, Timmann, Ehmen, Busch, Thye, Agbenyega.
Statistical analysis: May, Busch, Thye, Horstmann.
Obtained funding: May, Horstmann.
Administrative, technical, or material support: Evans, Timmann, Ehmen, Agbenyega, Horstmann.
Study supervision: Agbenyega, Horstmann.
Drs May and Evans contributed equally to this work.
Financial Disclosures: None reported.
Funding/Support: This study was supported by the German Federal Ministry of Education and Research through the National Genome Research Network.
Role of the Sponsor: The funding agency had no role in the design and conduct of the study; the analysis and interpretation of the data; or the preparation of the manuscript.
Disclaimer: The interpretation and reporting of these data are the sole responsibility of the authors.
Acknowledgment: We thank the participating children and their parents and guardians. Dr Agbenyega represents the Kumasi team of the Severe Malaria in African Children (SMAC) network, which includes Daniel Ansong, MD, Sampson Antwi, MD, Emanuel Asafo-Adjei, MD, Samuel Blay Nguah, MD, Kingsley Osei Kwakye, MD, Alex Osei Yaw Akoto, MD, and Justice Sylverken, MD, all of the Komfo Anokye Teaching Hospital, Kumasi. We appreciate the technical assistance of Lydia Nana Badu and Sophia Opoku, Kumasi Centre for Collaborative Research in Tropical Medicine, Kumasi; Mbort Attan-Ayibo and David Sambian, Komfo Anokye Teaching Hospital, Kumasi; and Jürgen Sievertsen, Bernhard Nocht Institute for Tropical Medicine, Hamburg. During the study period, the salaries of the individuals named were partly or entirely paid by the study grant.