Author Contributions: Dr Eng had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Eng.
Acquisition of data: Fukino, Patocs, Mutter.
Analysis and interpretation of data: Fukino, Shen, Patocs, Eng.
Drafting of the manuscript: Fukino, Shen, Eng.
Critical revision of the manuscript for important intellectual content: Fukino, Shen, Patocs, Mutter, Eng.
Statistical analysis: Shen.
Obtained funding: Eng.
Administrative, technical, or material support: Fukino, Shen, Patocs, Mutter, Eng.
Study supervision: Eng.
Financial Disclosures: None reported.
Funding/Support: This work was partially funded by grants P01CA97189-01A2 and P50CA113001-01 from the National Cancer Institute, Bethesda, Md (Dr Eng). Dr Eng is a recipient of the Doris Duke Distinguished Clinical Scientist Award.
Role of the Sponsor: The funding organization and sponsor had no role in the design and conduct of the study, in the collection, management, analysis, and interpretation of the data, or in the preparation, review, or approval of the manuscript. All analytical and interpretative work and drafting of the manuscript occurred under the direction of Dr Eng at the Cleveland Clinic Genomic Medicine Institute.
Acknowledgment: We thank Petra Platzer, PhD, Manager of Integrative Genomics Analysis, Cleveland Clinic Genomic Medicine Institute, for her critical review of drafts of the revised manuscript and for helpful discussions. Dr Platzer did not receive any compensation for her contribution.